A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
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چکیده
منابع مشابه
Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.
Our associated microbial communities play a critical role in human health and predisposition to disease, but the degree to which they also shape therapeutic interventions is not well understood. Here, we integrate results from classic and current studies of the direct and indirect impacts of the gut microbiome on the metabolism of therapeutic drugs and diet-derived bioactive compounds. We pay p...
متن کاملHost - microbial interactions in the metabolism of therapeutic and diet - derived xenobiotics
Introduction The human body is home to a complex microbial ecosystem. The gastrointestinal tract houses the most numerous microbial community (the gut microbiota), consisting of approximately 1013 microbial cells (1). Collectively, the aggregate genomes of the gut microbiota encode more than 100 times as many unique genes as the approximately 20,000 protein-coding genes found in the human genom...
متن کاملColonization-Induced Host-Gut Microbial Metabolic Interaction
UNLABELLED The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical environmental microbial background using high-resolution (1)H nuclear magnet...
متن کاملDoes canine inflammatory bowel disease influence gut microbial profile and host metabolism?
BACKGROUND Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis. Several studies have investigated the gut microbial ecology of dogs with IBD but it is yet unclear if this microbial profile can alter the nutrient metabolism of the host. The aim of the present stud...
متن کاملSystemic gut microbial modulation of bile acid metabolism in host tissue compartments.
We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver, kidney, heart, and blood plasma) in rats. We use a targeted ultra-performance liquid chromatography with time of flight mass-spectrometry assay to characterize the differential primary and secondary bile acid profiles in each tissue and show a major increase in the ...
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ژورنال
عنوان ژورنال: eLife
سال: 2020
ISSN: 2050-084X
DOI: 10.7554/elife.50845